Journal: Brain Pathology

Article Title: Central Nervous System Demyelination and Remyelination is Independent from Systemic Cholesterol Level in T heiler's Murine Encephalomyelitis

doi: 10.1111/bpa.12266

Figure Lengend Snippet: Canonical cholesterol biosynthesis pathway map in Theiler's murine encephalomyelitis. Transcriptional changes associated with cholesterol biosynthesis pathway in Theiler's murine encephalomyelitis virus (TMEV)‐infected mice in comparison with mock‐infected control mice, illustrated in the canonical cholesterol biosynthesis pathway map from Metacore™ database (Genego, St. Joseph, MI, USA). The bars labeled from one to four display the fold changes of significantly differentially regulated genes in TMEV‐infected animals (n = 6) compared with mock‐infected animals (n = 6) on 4 days post infection (dpi) employing pair‐wise Mann–Whitney U‐tests (P ≤ 0.05) (1 = 14 dpi; 2 = 42 dpi; 3 = 98 dpi; 4 = 196 dpi). The blue indicator scale of the bar marks the down‐regulation and displays a comparable measurement of the magnitude of the negative fold change. Green arrows = positive functional interaction; Z = catalysis; gray arrows = technical links; orange icons = enzymes; purple hexagons = generic compound; blue rectangle = normal process; gray rectangle = reaction. Acat1 = acetyl‐Coenzyme A acetyltransferase 1; Cyp51 = cytochrome P450, family 51; Dhcr24 = 24‐dehydrocholesterol reductase; Dhcr7 = 7‐dehydrocholesterol reductase; Ebp = phenylalkylamine Ca2+ antagonist (emopamil) binding protein; Fdft1 = farnesyl diphosphate farnesyl transferase 1; Fdps = farnesyl diphosphate synthetase; Ggps1 = geranylgeranyl diphosphate synthase 1; Hmgcr = 3‐hydroxy‐3‐methylglutaryl‐Coenzyme A reductase; Hmgcs1 = 3‐hydroxy‐3‐methylglutaryl‐Coenzyme A synthase 1; Idi1 = isopentenyl‐diphosphate delta isomerase; Idi2 = isopentenyl‐diphosphate delta isomerase 2; Lss = lanosterol synthase; Mvd = mevalonate (diphospho) decarboxylase; Mvk = mevalonate kinase; Nsdhl = NAD(P)‐dependent steroid dehydrogenase‐like; Pmvk = phosphomevalonate kinase; Sc4mol = sterol‐C4‐methyl oxidase‐like; Sc5d = sterol‐C5‐desaturase (fungal ERG3, delta‐5‐desaturase) homolog (Saccharomyces cerevisiae); Sqle = squalene epoxidase; Tm7sf2 = transmembrane 7 superfamily member 2.

Article Snippet: Transcriptional changes associated with cholesterol biosynthesis pathway in T heiler's murine encephalomyelitis virus ( TMEV )‐infected mice in comparison with mock‐infected control mice, illustrated in the canonical cholesterol biosynthesis pathway map from MetacoreTM database (Genego, S t. J oseph, MI, USA ).

Techniques: Virus, Infection, Comparison, Control, Labeling, MANN-WHITNEY, Functional Assay, Binding Assay